Trehalose

Trehalose is a naturally occurring disaccharide composed of two glucose molecules. It is known for its ability to stabilize proteins and enhance moisture retention in various formulations.

Clinical Evidence

Excipient substitution in botulinum toxin type A formulations

Trehalose has been shown to significantly improve the stability and aggregation resistance of botulinum neurotoxin type A (BoNT/A) formulations. In a study, trehalose formed more hydrogen bonds and exhibited better interaction energy compared to other excipients like sucrose and lactose, leading to superior stability and longer durations of efficacy. For more details, see Excipient substitution in botulinum toxin type A formulations: Insights from multi-scale in silico modelling.

Commensal-derived trehalose monocorynomycolate

Trehalose monocorynomycolate has been identified as a potent stimulator of protective immunity at the ocular surface, enhancing IL-17 production by γδ T cells. This highlights its potential therapeutic applications in strengthening immune defenses. For further reading, refer to Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity.

Pediatric Facial Demodicosis

In a rare case of pediatric facial demodicosis, the role of trehalose in skin health was indirectly highlighted through its moisture-retaining properties, which can be beneficial in managing skin conditions. More information can be found in The Hidden Culprit Unraveled by Dermoscopy: A Rare Case of Pediatric Facial Demodicosis.