Polysorbate 60

Overview

Polysorbate 60 is a non-ionic surfactant commonly used in cosmetic and pharmaceutical formulations for its emulsifying properties. It helps to stabilize mixtures of oil and water, enhancing the texture and application of products.

Clinical Evidence

Skin Permeation and Anti-inflammatory Efficacy

A study assessed the skin permeation and anti-inflammatory efficacy of lornoxicam proniosomal topical gel formulations, which included Polysorbate 60 as a surfactant. The results indicated improved skin permeation and significant anti-inflammatory effects compared to conventional formulations. For more details, see Assessment of skin permeation and anti-inflammatory efficacy of lornoxicam proniosomal topical gel formulations: a comparative study.

Emollients for Xerosis Cutis

Polysorbate 60 is often included in emollient formulations for treating xerosis cutis in atopic dermatitis. These emollients restore skin hydration and barrier function, proving effective in managing dry skin conditions. For further reading, refer to Basic Emollients for Xerosis Cutis in Atopic Dermatitis: A Review of Clinical Studies.

Wound Management

In the context of wound healing, Polysorbate 60 has been utilized in formulations to enhance the delivery and efficacy of therapeutic agents. A study on Aloe-emodin microemulsion gel highlighted the role of surfactants like Polysorbate 60 in optimizing wound management strategies. More information can be found in Aloe-emodin microemulsion gel for diabetic wounds: optimizing surfactant-polymer synergy for effective wound management.