Clinical Evidence on Panthenol

Efficacy in Actinic Keratoses Treatment

A study titled A Prebiotic and Panthenol-Containing Repair Balm Improves Tolerability of Topical 5-Fluorouracil Field Therapy for Actinic Keratoses: A Randomised Controlled Trial demonstrated that a panthenol-containing balm significantly reduced local skin reaction severity during treatment with topical 5-FU, enhancing patient quality of life.

Improvement in Skin Hydration and Barrier Function

Another trial, Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial, showed that a formulation with panthenol improved skin hydration and reduced transepidermal water loss in individuals with dry skin, indicating its effectiveness as a moisturizer.

Integrated Skincare Recommendations

The consensus from International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits highlights panthenol as a beneficial ingredient for enhancing skin tolerance and hydration during aesthetic procedures.