Adenosine

Overview

Adenosine is a nucleoside composed of adenine and ribose, playing a vital role in cellular energy transfer and signaling.

Clinical Evidence

Adenosine levels have been linked to disease severity in psoriasis. Elevated levels correlate with inflammation and immune dysregulation, as shown in studies like Microdialysis-based metabolomic and proteomic profiling reveals signature variations for disease severity in psoriasis.

Additionally, research indicates that CD73high fibroblasts produce adenosine, influencing keratinocyte inflammation in psoriasis, as detailed in CD73high fibroblasts orchestrate keratinocyte inflammation in the psoriasis-associated epithelial immune microenvironment.

Therapeutic Potential

Adenosine's role in modulating inflammation and cellular responses highlights its potential as a therapeutic target in dermatologic diseases, including insights from PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation.