iS Clinical Super Serum Advance+
VersusObagi Nu-Derm Clear Fx

iS Clinical Super Serum Advance+
Best For
All skin types, especially those concerned with fine lines, wrinkles, and uneven skin tone.
Best For
Normal to Oily, Normal to Dry, Combination skin types
Ingredient Profiles
iS Clinical Super Serum Advance+
iS Clinical Super Serum Advance+
Super Serum Advance+ is a scientifically advanced, clinically proven formula that combines a 15% concentration of L-Ascorbic Acid (Vitamin C) with bioidentical Copper Tripeptide-1. This serum helps reduce the appearance of fine lines and wrinkles, improves the look of hypertrophic scars and fine stretch marks, and safely brightens uneven skin tone while providing support against environmental stressors.
Evidence-Based Efficacy
The efficacy of Vitamin C and its role in skin health has been supported by various studies. For more information, refer to the following studies: The Role of Inflammatory Biomarkers in Disease Severity and Treatment Response across Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa-A Narrative Review and Advancing Precision Medicine in Inflammatory Skin Disease.
Obagi Nu-Derm Clear Fx
Obagi Nu-Derm Clear Fx is a skin-brightening cream specially formulated with nature-identical arbutin and antioxidants that helps improve the look of skin for an even, healthier-looking complexion. Research has shown that arbutin is effective in reducing hyperpigmentation and promoting an even skin tone. For more information, refer to the studies available on Europe PMC.
Safety & Application
Directions
Apply 3-4 drops to the palm of your hand. Using your fingertips, dab and smooth evenly over your face and neck. All iSClinical antioxidant formulations have been tested in final packaging and have been confirmed to remain stable and effective for 36 months, and up to 6 months after opening. L-ascorbic acid (pure vitamin C) is known to change color with time, however oxidation is minimal in SkinCeuticals antioxidant and the formulation is proven to remain effective. Science
Safety Notice
For external use only. Avoid contact with eyes. If irritation occurs, discontinue use.
Directions
Use twice a day, once during your morning routine and again during your nighttime routine.
Safety Notice
Sunburn Alert: This product contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards.



