iS Clinical Super Serum Advance+ vs Obagi 0.5 Smoothing Retinol

iS Clinical Super Serum Advance+
VersusObagi 0.5 Smoothing Retinol

Best For

All skin types, especially those concerned with fine lines, wrinkles, and uneven skin tone.

Best For

Normal to Oily, Normal to Dry, Combination skin types.

Ingredient Profiles

iS Clinical Super Serum Advance+

Super Serum Advance+ is a scientifically advanced, clinically proven formula that combines a 15% concentration of L-Ascorbic Acid (Vitamin C) with bioidentical Copper Tripeptide-1. This serum helps reduce the appearance of fine lines and wrinkles, improves the look of hypertrophic scars and fine stretch marks, and safely brightens uneven skin tone while providing support against environmental stressors.

Evidence-Based Efficacy

The efficacy of Vitamin C and its role in skin health has been supported by various studies. For more information, refer to the following studies: The Role of Inflammatory Biomarkers in Disease Severity and Treatment Response across Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa-A Narrative Review and Advancing Precision Medicine in Inflammatory Skin Disease.

Obagi 0.5 Smoothing Retinol

Obagi 0.5 Smoothing Retinol is a cream-based formula designed to renew your skin effectively. This potent yet gentle retinol helps to resurface the skin, minimising the appearance of fine lines and wrinkles while promoting skin turnover. Ideal for normal to oily, normal to dry, and combination skin types.

Evidence-Based Efficacy

Research supports the efficacy of retinol in promoting skin renewal and reducing signs of aging. For more information, see the following studies: Retinol and Skin Aging, Effects of Retinol on Skin.

Safety & Application

Directions

Apply 3-4 drops to the palm of your hand. Using your fingertips, dab and smooth evenly over your face and neck. All iS Clinical antioxidant formulations have been tested in final packaging and have been confirmed to remain stable and effective for 36 months, and up to 6 months after opening. L-ascorbic acid (pure vitamin C) is known to change color with time, however oxidation is minimal in SkinCeuticals antioxidant and the formulation is proven to remain effective. Science

Safety Notice

For external use only. Avoid contact with eyes. If irritation occurs, discontinue use.

Directions

Uncap the airless pump and apply 1 pump, or a pearl-sized amount to your face. Massage until fully absorbed. Use once daily in the evenings. Daily use of a broad spectrum sunscreen with an SPF of 30 or higher is highly recommended.

Safety Notice

When using this product, you may experience mild [redness](/concerns/redness), peeling, or skin irritation. These are normal, temporary indications the product is working. If irritation occurs, limit use to every other night, or as tolerated. Daily use of a broad spectrum sunscreen with an SPF of 30 or higher is highly recommended.

iS Clinical Super Serum Advance+
VersusObagi 0.5 Smoothing Retinol