iS Clinical Pro-Heal Serum Advance+
VersusObagi 0.5 Smoothing Retinol

iS Clinical Pro-Heal Serum Advance+
Best For
All skin types, especially blemish-prone and sensitive skin.
Best For
Normal to Oily, Normal to Dry, Combination skin types.
Ingredient Profiles
iS Clinical Pro-Heal Serum Advance+
Pro-Heal Serum Advance+ features our scientifically advanced L-Ascorbic Acid (Vitamin C), combined with a superior form of Olive Leaf Extract and pure Vitamins E and A. This powerful formulation significantly increases antioxidant protection while helping improve the appearance of compromised, blemish-prone, and aging skin. Clinical studies have shown that formulations containing L-Ascorbic Acid can significantly improve skin texture and reduce signs of aging. For more information, refer to the following studies: Enhancing Outcomes of Procedure Pairing With Next Generation Regenerating Skin Nectar With TriHex+ Technology and Transient immunostimulation with LPS promotes tissue repair in aged skin.
Obagi 0.5 Smoothing Retinol
- • Retinol
- • Ascorbic Acid
- • Calendula Officinalis Flower Extract
- • Camellia Sinensis Leaf Extract
- • Chamomilla Recutita Flower Extract
- • Dipotassium Glycyrrhizate
- • Sodium Hyaluronate
- • Tocopheryl Acetate
Obagi 0.5 Smoothing Retinol is a cream-based formula designed to renew your skin effectively. This potent yet gentle retinol helps to resurface the skin, minimizing the appearance of fine lines and wrinkles while promoting skin turnover. Ideal for normal to oily, normal to dry, and combination skin types.
Evidence-Based Efficacy
Research supports the efficacy of retinol in promoting skin renewal and reducing signs of aging. For more information, see the following studies: Retinol and Skin Aging, Effects of Retinol on Skin.
Safety & Application
Directions
Apply 3-4 drops to the palm of hand. Using fingertips, dab and smooth evenly over face and neck. All iSClinical antioxidant formulations have been tested in final packaging and have been confirmed to remain stable and effective for 36 months, and up to 6 months after opening. L-ascorbic acid (pure vitamin C) is known to change color with time, however oxidation is minimal in SkinCeuticals antioxidant and the formulation is proven to remain effective. Science
Safety Notice
For external use only. Avoid contact with eyes. If irritation occurs, discontinue use.
Directions
Uncap the airless pump and apply 1 pump, or a pearl-sized amount to your face. Massage until fully absorbed. Use once daily in the evenings.
Safety Notice
When using this product, you may experience mild [redness](/concerns/redness), peeling, or skin irritation. These are normal, temporary indications the product is working. If irritation occurs, limit use to every other night, or as tolerated. Daily use of a broad spectrum sunscreen with an SPF of 30 or higher is highly recommended.



