Sodium Bisulfite

Overview

Sodium bisulfite is a chemical compound commonly used as a preservative and antioxidant in various formulations, including pharmaceuticals and cosmetics.

Clinical Evidence

Contact Dermatitis Case Report

A study reported a case of bromfenac with sodium bisulfite preservative inducing contact dermatitis and a secondary sterile corneal ring infiltrate. The patient experienced dermatitis after using bromfenac ophthalmic drops containing sodium bisulfite. The dermatitis resolved after discontinuation of the drops, but the corneal ring ulcer persisted. Caution is advised for patients with sulfite sensitivity or allergy. Bromfenac with Sodium Bisulfite Inducing Contact Dermatitis and Corneal Ring Infiltrate: A Case Report

Skin-Lightening Preparation

Another study explored a green formulation of menadione-loaded niosome using sodium bisulfite, which showed improved dermal delivery and anti-melanogenesis activities. The optimized formulation demonstrated minimal side effects and enhanced skin absorption. Green Formulation of Menadione-Loaded Niosome as a Skin-Lightening Preparation

Antioxidant Stability

Sodium bisulfite has been studied for its role in enhancing the stability of crude proanthocyanidins extract from peanut skins, which exhibits significant antioxidant activities. The extract shows favorable stability under various conditions, making it a potential natural antioxidant in food processing. Exploring the extraction, antioxidant activities and its stabilities of peanut skins crude proanthocyanidins extract