Mannitol

Overview

Mannitol is a sugar alcohol that serves as a humectant and osmotic agent in various skincare formulations. It helps to retain moisture in the skin, providing hydration and improving skin texture.

Clinical Evidence

Mannitol has been identified as a potential contributor to drug hypersensitivity reactions, particularly in formulations containing multiple excipients. According to the study titled Hypersensitivity to Excipients in Drugs: An EAACI Position Paper, mannitol is among the common culprits of drug hypersensitivity reactions.

Additionally, its role in biological photoprotection is highlighted in the review Biological Photoprotection: A Review of its Mechanisms, Evidence, and Clinical Implications, suggesting that it may enhance skin's defense against environmental stressors.

Conclusion

Mannitol is a versatile ingredient in skincare, valued for its hydrating properties and potential role in enhancing skin protection mechanisms.