Manganese

Overview

Manganese is a trace mineral that plays a crucial role in various physiological processes, including antioxidant defense and bone formation.

Clinical Evidence

Recent studies have highlighted the immunomodulatory effects of manganese, particularly in the context of nanoparticles. For instance, a study titled Examining the immunomodulatory role of nanoparticles on mast cell activation found that manganese doped titanium dioxide nanoparticles exacerbated allergic reactions in a mouse model.

Additionally, research on the impact of long-term cryopreservation on serum profiles indicated that manganese levels can significantly change, affecting the validity of biobanked materials (Impact of long-term cryopreservation on serum proteome and metallome).

Furthermore, manganese levels in nails have been associated with the severity of nail psoriasis, suggesting its potential as a biomarker for disease activity (Nail Amino Acid and Trace Element Profiles and Their Association with Clinical Severity in Nail Psoriasis).