Clinical Evidence on Fatty Acids

The Cutaneous Microbiome

The human skin microbiome exists within a lipid-rich environment that profoundly shapes microbial colonization, metabolism, and interactions with the host. Resident microbes consume host-derived lipids for energy and transform them into bioactive compounds that influence microbial competition, immune responses, and skin barrier function. Microbially generated lipids contribute to maintaining homeostasis and can influence disease processes such as acne and atopic dermatitis. For more details, see The cutaneous microbiome: microbial remodeling of the skin lipid landscape.

Integrative Dermatology for Longevity

Skin aging reflects both intrinsic biological decline and extrinsic influences, including UV radiation and air pollution. An integrative approach combining topical treatments and internal nutraceuticals targets key hallmarks of aging, oxidative stress, and inflammation, promoting skin regeneration. For further insights, refer to Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches.

Cold Stress and Psoriasis

Cold stress can exacerbate psoriasis by promoting the development of psoriasis-like lesions. This is linked to the remodeling of macrophage phenotypes and increased lipid synthesis in dermal adipocytes. Targeting these macrophages may help prevent psoriasis worsening in winter. More information can be found in Cold Stress Activates ACSL1+ Macrophages in a Fatty Acid-Dependent Manner to Exacerbate Psoriasis.