Clinical Evidence

Photoaging Assessment

Bakuchiol has been evaluated for its effects on photoaging in a controlled study involving a Chinese population. The findings suggest significant improvements in skin quality, comparable to retinol, but with better tolerability. For more details, see Prospective, Double‐Blind, Vehicle‐Controlled Assessment of Topical Bakuchiol on Photoaging in a Chinese Population.

Mechanistic Insights

Bakuchiol acts similarly to retinol by modulating gene expression related to skin aging. It influences various biological pathways, enhancing skin resilience and repair. For an in-depth review, refer to Bakuchiol: From structural mimicry to systems-level skin biology.

Toxicity Concerns

Despite its benefits, bakuchiol has been identified as a potentially toxic component in Fructus psoraleae, causing liver damage in vitro. This highlights the need for caution in its use. More information can be found in the study Bakuchiol, a potentially toxic component in Fructus psoraleae, causes liver damage in vitro by affecting the homeostasis of the liver GABA signalling system.