Azelaic Acid

Overview

Azelaic acid is a dicarboxylic acid that is commonly used in dermatology for its anti-inflammatory and keratolytic properties. It is effective in treating acne and hyperpigmentation, making it a versatile ingredient in skincare.

Clinical Evidence

Extra-facial Melasma

A case study highlighted the use of topical azelaic acid in treating extra-facial melasma in a male patient, emphasizing its role in managing hyperpigmentation despite limited improvement due to ongoing UV exposure. For more details, see Extra-facial Melasma Presenting With Isolated Forearm Involvement in a Male Patient.

Perioral Dermatitis

Azelaic acid is also noted as a treatment option for perioral dermatitis, which is often triggered by steroid use. It is included among various treatment modalities for this condition. For further reading, refer to The Treatment of Perioral (Periorificial) Dermatitis With Topical Roflumilast 0.3% Cream.

Integrated Skincare

In a consensus on integrated skincare, azelaic acid was identified as unsuitable for use on treatment day but remains a valuable ingredient for pre-treatment and aftercare in aesthetic procedures. More information can be found in International Expert Consensus on Integrated Skincare Active Ingredients.