Clinical Evidence

Enhanced Whitening Effect

4-n-butylresorcinol, in combination with licochalcone A and glabridin, shows enhanced skin whitening by inhibiting tyrosinase activity. Enhanced Whitening Effect of the Formulations via Inhibition of Tyrosinase Activity by Combination of 4-n-Butylresorcinol, Licochalcone A and Glabridin at an Optimal Ratio

Next-Generation Tyrosinase Inhibitor

KT-939, a new human tyrosinase inhibitor, demonstrates superior efficacy for managing hyperpigmentation, outperforming traditional agents. KT-939: A Next-Generation Human Tyrosinase Inhibitor With Superior Efficacy for the Safe Management of Hyperpigmentation

Supramolecular System for Whitening

A supramolecular system combining 4-butylresorcinol and licochalcone A enhances skin permeation and whitening effects, significantly reducing melanin content. Co-delivery of loaded 4-butylresorcinol and licochalcone A in a supramolecular system for synergistic permeation and whitening effects