Polynucleotides

Polynucleotides

Dr Martyn King | Cosmedic Skin Clinic | Staffordshire

Polynucleotides are an advanced regenerative injectable treatment designed to improve skin quality, stimulate tissue repair, and support natural collagen production. Rather than adding volume like dermal fillers, polynucleotides work by encouraging cellular regeneration and improving the health of the skin from within.

Often referred to as a form of regenerative aesthetics, polynucleotide treatments can improve skin texture, elasticity, hydration, and overall skin quality while helping to reduce the visible signs of ageing. They are particularly popular for delicate areas such as around the eyes, where traditional fillers may not always be appropriate.

Summary

• Procedure time: 30–45 minutes
• Downtime: Minimal (mild swelling and injection marks may be visible for 24–72 hours) 
• Discomfort: Mild
• Anaesthetic: Topical anaesthetic cream available if required 
• Onset of results: 2–4 weeks
• Peak/final results: 8–12 weeks following treatment course 
• Duration: Approximately 6–12 months
• Maintenance: Usually a course of 2–4 treatments spaced 2–4 weeks apart, followed by maintenance treatments every 6–12 months

Pricing

Prices vary depending on the treatment area, product selection, and treatment plan.

Typical Treatment Prices

• Single treatment session: £275
• Course of 3 treatments: £725

💡 Final cost is confirmed after consultation based on treatment area, skin condition, and individual treatment goals.

How it works

Polynucleotides are highly purified DNA fragments that support tissue regeneration and cellular repair. Once injected into the skin, they help create an optimal environment for fibroblasts, the cells responsible for producing collagen and elastin.

Polynucleotides work by:

• Stimulating collagen production
• Improving skin hydration
• Supporting tissue repair and regeneration
• Reducing inflammation
• Improving skin elasticity
• Protecting against oxidative stress

Treatment involves a series of small injections placed into the superficial and mid-dermis. The procedure is tailored according to the treatment area and desired outcome.

Unlike fillers, results develop gradually as the skin repairs and remodels itself over several weeks.

What areas can be treated

Polynucleotides are particularly effective for:

Facial Rejuvenation

• Face
• Periorbital area (around the eyes)
• Crow's feet
• Forehead
• Cheeks
• Lower face

Skin Quality Improvement

• Neck
• Décolletage
• Hands

Specialist Applications

• Acne scars
• Fine lines and wrinkles
• Skin laxity
• Sun-damaged skin
• Delicate and thin skin around the eyes

Am I suitable?

You may be suitable if you:

• Want to improve skin quality naturally
• Have fine lines and early signs of ageing
• Notice skin laxity or loss of elasticity
• Have tired-looking or crepey skin around the eyes
• Wish to stimulate collagen production without adding volume
• Prefer regenerative treatments with natural-looking results

You may not be suitable if you:

• Are pregnant or breastfeeding
• Have an active skin infection in the treatment area
• Have certain autoimmune or inflammatory conditions
• Have a known allergy to product ingredients
• Are unsuitable for injectable treatments

A full consultation is required to determine suitability.

Pre-treatment advice

Before treatment:

• Avoid alcohol for 24 hours
• Avoid aspirin and anti-inflammatory medications unless prescribed
• Stay well hydrated
• Attend with clean skin where possible
• Inform your practitioner of any medications, allergies, or previous injectable treatments
• Avoid scheduling treatment immediately before important social events

Post-treatment advice

After treatment:

• Avoid touching or massaging the treated area for 24 hours
• Avoid strenuous exercise for 24–48 hours
• Avoid excessive heat, saunas, steam rooms, and sunbeds for 48 hours
• Continue using daily SPF protection
• Keep the skin hydrated
• Follow any personalised aftercare instructions provided

Small injection-site bumps may be visible for a short period and usually settle naturally.

Side-effects & complications

Polynucleotide treatments are generally very well tolerated.

Common (temporary):

• Mild redness
• Swelling
• Tenderness
• Bruising
• Temporary injection-site bumps

Less common:

• Prolonged swelling
• Mild asymmetry during healing
• Delayed inflammatory reaction

Rare:

• Infection
• Allergic reaction
• Persistent nodules
• Vascular complications (extremely rare)

As with all injectable treatments, risks are minimised through appropriate assessment and experienced administration.

Benefits

• Stimulates natural collagen production
• Improves skin elasticity and firmness
• Enhances hydration and skin quality
• Supports tissue regeneration and repair
• Improves delicate eye-area skin
• Softens fine lines and wrinkles
• Natural-looking results
• Suitable for preventative and corrective ageing treatments
• Can be combined with other regenerative and aesthetic procedures

Advice from Dr Martyn King

Dr Martyn King, Cosmedic Skin Clinic, Staffordshire

"Polynucleotides represent one of the most exciting developments in regenerative aesthetics. Rather than simply filling or masking signs of ageing, they help improve the quality and function of the skin itself. They are particularly valuable for patients seeking natural rejuvenation and for treating delicate areas where skin quality is the primary concern."